On the hydrolysis of diethyl 2-(perfluorophenyl)malonate

• Ilya V. Taydakov and
• Mikhail A. Kiskin

Beilstein J. Org. Chem. 2020, 16, 1863–1868, doi:10.3762/bjoc.16.153

• resulting compound was considered as a starting material for synthesizing 2-(perfluorophenyl)malonic acid by hydrolysis. It was found that the desired 2-(perfluorophenyl)malonic acid could not be obtained from this ester by hydrolysis, neither under basic nor under acidic conditions. Nevertheless

• . Keywords: decarboxylation; fluorinated aromatic compounds; hydrolysis of esters; 2-(perfluorophenyl)acetic acid; 2-(perfluorophenyl)malonic acid; Introduction 2-Phenylmalonic acid (1) and its esters are useful and versatile intermediates in the synthesis of many practically important compounds, e.g

• range by fluorination (directly or indirectly) of initial organic molecules. In the ongoing project, we are interested in synthesizing 2-(perfluorophenyl)malonic acid (2, Figure 1) as a new ligand for the preparation of 3d and 4f heterometallic coordination compounds. Results and Discussion To our